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GR 55562 dihydrochloride

Names

[ CAS No. ]:
159533-25-2

[ Name ]:
GR 55562 dihydrochloride

[Synonym ]:
3-[3-(Dimethylamino)propyl]-4-hydroxy-N-[4-(pyridin-4-yl)phenyl]benzamide dihydrochloride
3-[3-(Dimethylamino)propyl]-4-hydroxy-N-[4-(4-pyridinyl)phenyl]benzamide dihydrochloride
Benzamide, 3-[3-(dimethylamino)propyl]-4-hydroxy-N-[4-(4-pyridinyl)phenyl]-, hydrochloride (1:2)
MFCD06201848
MFCD01861177

Biological Activity

[Description]:

GR 55562 (dihydrochloride) is a selective 5-HT1B receptor antagonist. GR 55562 can be used for the research of nerve disease[1].

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor
Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[In Vivo]

GR 55562 (0.1-10 μg/side) 进入伏隔子区域不会引起cocaine杠杆响应[1]。 GR 55562 (0.1-10 μg/side)（伏核壳或核中）的未能调节cocaine（5 mg/kg）的辨别作用[1]。 GR 55562 (1 μg/side) 显着减弱了对cocaine的辨别作用[1]。 Animal Model: Male Wistar rats (280-300 g; n=50)[1]. Dosage: 0.1-10 μg/side Administration: Injected intracranially; At a volume of 0.2 µl/side Result: Did not evoke substitution for the drug with intra-accumbal shell infusion. Did not significantly affect the discriminative stimulus effects produced by 5 mg/kg of cocaine. GR 55562 (1 µg/side) attenuated the enhancement of cocaine discrimination evoked by a combination of intra-accumbal core CP 93129 (1 µg/side) and systemic cocaine (1.25 mg/ kg or 2.5 mg/kg).

[References]

[1]. Filip M, et al. Effects of serotonin (5-HT)(1B) receptor ligands, microinjected into accumbens subregions, on cocaine discrimination in rats. Naunyn Schmiedebergs Arch Pharmacol. 2002;366(3):226-234.  

Chemical & Physical Properties

[ Molecular Formula ]:
C23H27Cl2N3O2

[ Molecular Weight ]:
448.39

[ Exact Mass ]:
447.148041

Related Compounds