Paramethasone Acetate
Names
[ CAS No. ]:
1597-82-6
[ Name ]:
Paramethasone Acetate
[Synonym ]:
PARAMETHASONE ACETATE
DSSTox_CID_3422
Paramethasone-21-acetate
Biological Activity
[Description]:
[Related Catalog]:
Chemical & Physical Properties
[ Density]:
1.29 g/cm1.29 g/cm3
[ Boiling Point ]:
584.2ºC at 760 mmHg
[ Melting Point ]:
>148°C (dec.) (lit.)
[ Molecular Formula ]:
C24H31FO6
[ Molecular Weight ]:
434.49800
[ Flash Point ]:
307.1ºC
[ Exact Mass ]:
434.21000
[ PSA ]:
100.90000
[ LogP ]:
2.32240
[ Vapour Pressure ]:
4.42E-16mmHg at 25°C
[ Index of Refraction ]:
1.569
[ Storage condition ]:
2-8°C
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TU4025000
- CHEMICAL NAME :
- Pregna-1,4-diene-3,20-dione, 6-alpha-fluoro-11-beta,17,21-trihydroxy-16-alpha-meth yl-, 21-acetate
- CAS REGISTRY NUMBER :
- 1597-82-6
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C24-H31-F-O6
- MOLECULAR WEIGHT :
- 434.55
- WISWESSER LINE NOTATION :
- L E5 B666 OV AHTTT&J A1 CQ E1 FV1OV1 FQ G1 LF
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 392 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,185,1971
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,588,1982 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Unreported
- DOSE :
- 10500 ug/kg
- SEX/DURATION :
- female 1-21 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
- REFERENCE :
- NFGZAD Nippon Funin Gakkai Zasshi. Japanese Journal of Fertility and Sterility. (Nippon Funin Gakkai, 1-1 Sadohara-cho, Ichigaya, Shinjuku-ku, Toyko 162, Japan) V.1- 1956- Volume(issue)/page/year: 13,211,1968
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Unreported
- DOSE :
- 2625 ug/kg
- SEX/DURATION :
- female 1-21 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord)
- REFERENCE :
- NFGZAD Nippon Funin Gakkai Zasshi. Japanese Journal of Fertility and Sterility. (Nippon Funin Gakkai, 1-1 Sadohara-cho, Ichigaya, Shinjuku-ku, Toyko 162, Japan) V.1- 1956- Volume(issue)/page/year: 13,211,1968 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1177 No. of Facilities: 33 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 297 (estimated)
Safety Information
[ Hazard Codes ]:
Xn