T-448

Names

[ Name ]:
T-448

Biological Activity

[Description]:

T-448 is a specific and irreversible inhibitor of lysine-specific demethylase 1 (LSD1, an H3K4 demethylase), with an IC50 of 22 nM. T-448 enhances H3K4 methylation in primary cultured rat neurons[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> Histone Demethylase

Research Areas >> Neurological Disease

[Target]

IC50: 22 nM (LSD1)[1].

[References]

[1]. Matsuda S, et al. T-448, a specific inhibitor of LSD1 enzyme activity, improves learning function without causing thrombocytopenia in mice. Neuropsychopharmacology. 2018 Dec 22.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₈H₄₄N₈O₆S₂

[ Molecular Weight ]:
772.94

T-448

Names

Biological Activity

Chemical & Physical Properties

Related Compounds