Tilfrinib

Names

[ Name ]:
Tilfrinib

[Synonym ]:
3-(9H-Pyrido[2,3-b]indol-4-ylamino)phenol
Phenol, 3-(9H-pyrido[2,3-b]indol-4-ylamino)-
MFCD30011871

Biological Activity

[Description]:

Tilfrinib (compound 4f) is a potent and selective inhibitor of breast tumor kinase (Brk) with an IC50 of 3.15 nM, which displays anti-proliferative activity and acts as a promising antitumor agent[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[Target]

IC50: 3.15 nM (Brk)[1]

[References]

[1]. Mahmoud KA, et al. Discovery of 4-anilino α-carbolines as novel Brk inhibitors. Bioorg Med Chem Lett. 2014 Apr 15;24(8):1948-51.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
560.6±35.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₁₃N₃O

[ Molecular Weight ]:
275.305

[ Flash Point ]:
292.8±25.9 °C

[ Exact Mass ]:
275.105865

[ LogP ]:
4.69

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.839