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N-[(1S,5R)-7,9-dimethyl-7,9-diazabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide dihydrochloride

Names

[ CAS No. ]:
160472-97-9

[ Name ]:
N-[(1S,5R)-7,9-dimethyl-7,9-diazabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide dihydrochloride

[Synonym ]:
Indisetron hydrochloride (JAN)
Sinseron (TN)
UNII-NBN3HB12DW
N-3389
Indisetron hydrochloride
Indisetron HCl Nisshin
Sinseron

Biological Activity

[Description]:

Indisetron dihydrochloride is a 5-HT3 receptor antagonist with anti-emetic activity.

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor
Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[References]

[1]. Nakatsumi H, et al. Optimal dose period for indisetron tablets for preventing chemotherapy-induced nausea and vomiting with modified FOLFOX6: a randomized pilot study. Chemotherapy. 2012;58(6):439-44.  

Chemical & Physical Properties

[ Boiling Point ]:
574.4ºC at 760mmHg

[ Molecular Formula ]:
C17H25Cl2N5O

[ Molecular Weight ]:
386.32

[ Flash Point ]:
301.2ºC

[ Exact Mass ]:
385.14400

[ PSA ]:
64.26000

[ LogP ]:
2.94020

[ Vapour Pressure ]:
3.36E-13mmHg at 25°C

Related Compounds