LX2761

Names

[ Name ]:
LX2761

Biological Activity

[Description]:

LX2761 is chemically stable and potent inhibitor against sodium-dependent glucose cotransporter 1 (SGLT1) and SGLT2 in vitro with IC50s of 2.2 nM and 2.7nM for hSGLT1 and hSGLT2, but displays specific SGLT1 inhibition in the gastrointestinal (GI) tract[1].

[Related Catalog]:

Research Areas >> Metabolic Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> SGLT

[Target]

IC50: 2.2 nM (hSGLT1), 2.7nM (hSGLT2)[1]

[References]

[1]. Goodwin NC, et al. Discovery of LX2761, a Sodium-Dependent Glucose Cotransporter 1 (SGLT1) Inhibitor Restrictedto the Intestinal Lumen, for the Treatment of Diabetes. J Med Chem. 2017 Jan 26;60(2):710-721.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₂H₄₇N₃O₆S

[ Molecular Weight ]:
601.31