Cromoglicic acid

Names

[ Name ]:
Cromoglicic acid

[Synonym ]:
Acidum cromoglicicum
cromolyn
EINECS 240-279-8
Nalcrom
Acide cromoglicique
1,3-bis(2-carboxychromon-5-yloxy)-2-hydroxy propane
1,3-bis(2-carboxy-chromon-5-yloxy)-propan-2-ol
5-[3-(2-carboxy-4-oxochromen-5-yl)oxy-2-hydroxypropoxy]-4-oxochromene-2-carboxylic acid
MFCD00057744
Cromoglicic acid
Cromoglycate
Acido cromoglicico
5,5'-(2-hydroxypropane-1,3-diyl)bis(oxy)bis(4-oxo-4H-chromene-2-carboxylic acid)
Lomudal
Lomusol

Biological Activity

[Description]:

Cromolyn is a mast cell stabilizer. Cromolyn has the potential for the research of bronchial asthma, allergic rhinitis, and certain allergic eye conditions such as vernal conjunctivitis, keratitis, and keratoconjunctivitis[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Minutello K, et al. Cromolyn Sodium.

Chemical & Physical Properties

[ Density]:
1.623

[ Boiling Point ]:
752.3ºC at 760 mmHg

[ Melting Point ]:
241-242ºC

[ Molecular Formula ]:
C₂₃H₁₆O₁₁

[ Molecular Weight ]:
468.37

[ Flash Point ]:
263.9ºC

[ Exact Mass ]:
468.06900

[ PSA ]:
173.71000

[ LogP ]:
2.11450

[ Vapour Pressure ]:
1.08E-23mmHg at 25°C

[ Index of Refraction ]:
1.681

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ2365000

CHEMICAL NAME :: 4H-1-Benzopyran-2-carboxylic acid, 5,5'-((2-hydroxy-1,3-propanediyl)bis(oxy))bis(4-oxo-

CAS REGISTRY NUMBER :: 16110-51-3

LAST UPDATED :: 199606

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C23-H16-O11

MOLECULAR WEIGHT :: 468.39

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4407810

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26-36

[ WGK Germany ]:
2

[ RTECS ]:
DJ2380000

[ HS Code ]:
2922499990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%