Benzyl-PEG8-THP

Names

[ Name ]:
Benzyl-PEG8-THP

[Synonym ]:
MFCD29049395
2-[(1-Phenyl-2,5,8,11,14,17,20,23-octaoxapentacosan-25-yl)oxy]tetrahydro-2H-pyran
2H-Pyran, tetrahydro-2-[(25-phenyl-3,6,9,12,15,18,21,24-octaoxapentacos-1-yl)oxy]-
Benzyl-PEG8-THP

Biological Activity

[Description]:

Benzyl-PEG8-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
602.0±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₈H₄₈O₁₀

[ Molecular Weight ]:
544.675

[ Flash Point ]:
224.1±31.4 °C

[ Exact Mass ]:
544.324768

[ LogP ]:
-0.48

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.499

Benzyl-PEG8-THP

Names

Biological Activity

Chemical & Physical Properties

Related Compounds