AT-9010 tetrasodium

Names

[ Name ]:
AT-9010 tetrasodium

Biological Activity

[Description]:

AT-9010 tetrasodium, a triphosphate active metabolite of AT-527, is a potent inhibitor of NiRAN (a function essential for viral replication). AT-9010 tetrasodium can inhibit SARS-CoV-2 replication[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> SARS-CoV

[Target]

NiRAN[1]

[In Vitro]

Substantial levels of the active triphosphate metabolite AT-9010 are formed in normal human bronchial and nasal epithelial cells incubated with 10 µM AT-511 (698 µM and 236 µM, respectively), with a half-life of at least 38 hours[1].

[References]

[1]. Atea Pharmaceuticals Announces Publication of Preclinical Data Highlighting Potent Activity of AT-527 Against SARS-CoV-2. BOSTON, Feb. 08, 2021. Atea Pharmaceuticals, Inc.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₁H₁₃FN₅Na₄O₁₃P₃

[ Molecular Weight ]:
627.13

Safety Information

[ Hazard Codes ]:
Xi

AT-9010 tetrasodium

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Related Compounds