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Laprituximab

Names

[ CAS No. ]:
1622327-38-1

[ Name ]:
Laprituximab

Biological Activity

[Description]:

Laprituximab (J2898A) is a humanized IgG1 anti-EGFR antibody that can be used for the synthesis of ADC IMGN289[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> JAK/STAT Signaling >> EGFR

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

[In Vivo]

在 H292 异种移植瘤模型中，Laprituximab (J2898A) 的最低有效剂量为 3 mg/kg[1]。

[References]

[1]. Chittenden T D, et al. IMGN289, an EGFR-targeting antibody-maytansinoid conjugate with potent activity against non-small cell lung cancer (NSCLC) regardless of dependency on EGFR pathway. Cancer Research, 2013, 73(8_Supplement): 5467-5467.

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds