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Aurantimycin A

Names

[ CAS No. ]:
162478-50-4

[ Name ]:
Aurantimycin A

[Synonym ]:
Aurantimycin
(2R)-N-[(4aR,7S,16aS,19R,22S,23S)-6,18-Dihydroxy-22-isopropyl-7-(methoxymethyl)-19-methyl-5,8,11,17,20,24-hexaoxodocosahydro-13H,22H-dipyridazino[6,1-f:6',1'-o][1,4,7,10,13,16]oxapentaazacyclononadecin-23-yl]-2-hydroxy-2-[(2S,5S,6S)-2-hydroxy-5-isobutyl-6-methyltetrahydro-2H-pyran-2-yl]propanamide

Biological Activity

[Description]:

Aurantimycin A (Adipogen), a depsipeptide antibiotic, displays strong activity against Gram-positive bacteria. Aurantimycin A is a substrate of the LieAB transporter[1][2].

[Related Catalog]:

Research Areas >> Infection
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. U Gräfe, et al. Aurantimycins, new depsipeptide antibiotics from Streptomyces aurantiacus IMET 43917. Production, isolation, structure elucidation, and biological activity. J Antibiot (Tokyo). 1995 Feb;48(2):119-25.  

[2]. Samuel Hauf, et al.Aurantimycin resistance genes contribute to survival of Listeria monocytogenes during life in the environment. Mol Microbiol. 2019 Apr;111(4):1009-1024.  

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C38H64N8O14

[ Molecular Weight ]:
856.96

[ Exact Mass ]:
856.454224

[ LogP ]:
-3.99

[ Index of Refraction ]:
1.603

Related Compounds