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Gü2602

Names

[ CAS No. ]:
1627094-88-5

[ Name ]:
Gü2602

Biological Activity

[Description]:

Gü2602 is a potent, reversible cathepsin K (CatK) inhibitor with a Ki of 0.013 nM for mature CatK (mCatK). Gü2602 suppresses the autocatalytic activation of the cathepsin K zymogen[1].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Metabolic Enzyme/Protease >> Cathepsin

[Target]

Ki: 0.013 nM (mCatK)[1]


[References]

[1]. Benýšek J, et al. Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes. J Enzyme Inhib Med Chem. 2022 Dec;37(1):515-526.

Chemical & Physical Properties

[ Molecular Formula ]:
C16H22N4O3

[ Molecular Weight ]:
318.37

Related Compounds