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TAK-020

Names

[ CAS No. ]:
1627603-21-7

[ Name ]:
TAK-020

Biological Activity

[Description]:

TAK-020 is a covalent Btk inhibitor, which becomes the clinical candidate.

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Btk

[References]

[1]. Sabat M, et al. Discovery of the Bruton's Tyrosine Kinase Inhibitor Clinical Candidate TAK-020 (S)-5-(1-((1-Acryloylpyrrolidin-3-yl)oxy)isoquinolin-3-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one, by Fragment-Based Drug Design. J Med Chem. 2021 Sep 9;64(17):12893-12902.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₁₇N₅O₃

[ Molecular Weight ]:
351.36

Related Compounds