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IEM 1754 2HBr

Names

[ CAS No. ]:
162831-31-4

[ Name ]:
IEM 1754 2HBr

[Synonym ]:
1,5-Pentanediamine, N-(tricyclo[3.3.1.1]dec-1-ylmethyl)-, hydrobromide (1:2)
N-(Adamantan-1-ylmethyl)-1,5-pentanediamine dihydrobromide
IEM 1754 2HBr
IEM 1754 Dihydrobromide

Biological Activity

[Description]:

IEM-1754, a dicationic adamantane derivative, is a potent blocker of open channels of native ionotropic glutamate receptors including quisqualate-sensitive receptors in insect muscles, NMDAR in cultured rat cortical neurons, and AMPAR in freshly isolated hippocampal cells. IEM-1754 shows anticonvulsant potency in vivo[1][2].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR
Research Areas >> Neurological Disease
Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[References]

[1]. Tikhonov DB, et al. Voltage-dependent block of native AMPA receptor channels by dicationic compounds. Br J Pharmacol. 2000 Jan;129(2):265-74.

[2]. Lukomskaia NIa, et al. [Comparison of the anticonvulsant activity of organic mono- and di-cations and their potential to inhibit NMDA and AMPA glutamate receptors]. Ross Fiziol Zh Im I M Sechenova. 2002 Sep;88(9):1161-71. Russian.

Chemical & Physical Properties

[ Molecular Formula ]:
C16H32Br2N2

[ Molecular Weight ]:
412.25

[ Exact Mass ]:
410.093201

[ PSA ]:
38.05000

[ LogP ]:
4.97070

[ Storage condition ]:
-20℃

Related Compounds