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cGAS inhibitor 467

Names

[ CAS No. ]:
1628332-52-4

[ Name ]:
cGAS inhibitor 467

Biological Activity

[Description]:

GSK467 is a selective KDM5 (JARID1) inhibitor with a Ki of 10 nM for KDM5B, shows 180-fold selectivity for KDM4C and no measurable inhibitory effects toward KDM6 or other Jumonji family members[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Epigenetics >> Histone Demethylase

[Target]

Ki: 10 nM (KDM5B)[1]


[References]

[1]. Johansson C, et al. Structural analysis of human KDM5B guides histone demethylase inhibitor development. Nat Chem Biol. 2016 Jul;12(7):539-45.

Chemical & Physical Properties

[ Molecular Formula ]:
C17H13N5O2

[ Molecular Weight ]:
319.32

[ Storage condition ]:
2-8℃

Related Compounds