BAY-784

Names

[ Name ]:
BAY-784

Biological Activity

[Description]:

BAY-784 is a gonadotropin releasing hormone receptor (GnRH-R) antagonist probe with IC50s of 21 and 24 nM for human and rat GnRH-R, respectively[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> GNRH Receptor

Research Areas >> Cancer

[Target]

IC50: 21 nM (human GnRH-R), 24 nM (rat GnRH-R)[1]

[In Vivo]

BAY-784 (0.5, 3, 10, and 30 mg/kg; 24 hours; single p.o.) suppresses the plasma luteinizing hormone (LH) concentration in ovariectomized (OVX) rats in a dose-dependent manner[1]. Animal Model: OVX rats[1] Dosage: 0.5, 3, 10, and 30 mg/kg (Pharmacokinetic Analysis) Administration: Single p.o. Result: ED50=4.5 mg/kg (4/8 h). The t1/2=13-17 h, 18 h, and 7 h for male Wistar rat, female beagle, and female cynomolgus, respectively.

[References]

[1]. GnRH-R Antagonist Probe BAY-784.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₉H₂₆ClF₄N₃O₅S₂

[ Molecular Weight ]:
672.11

BAY-784

Names

Biological Activity

Chemical & Physical Properties

Related Compounds