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Biotinylated-JQ1

Names

[ CAS No. ]:
1635437-52-3

[ Name ]:
Biotinylated-JQ1

Biological Activity

[Description]:

Biotinylated-JQ1 (Biotin-JQ1) is a biotinylated derivative of JQ1 with high affinity for the bromodomain of BRD4. Biotinylated-JQ1 inhibits MM1.S multiple myeloma cells proliferation with the EC50 of 0.4 μM[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain

[In Vitro]

Biotinylated-JQ1 (0.1 nM-100 μM; 72 hours) inhibits MM1.S cell proliferation with an EC50 of 0.4 μM[1].

[References]

[1]. Lars Anders, et al. Genome-wide localization of small molecules. Nat Biotechnol. 2014 Jan;32(1):92-6.

Chemical & Physical Properties

[ Molecular Formula ]:
C39H53ClN8O6S2

[ Molecular Weight ]:
829.47

Related Compounds