LolCDE-IN-1

Names

[ CAS No. ]:
1639933-78-0

[ Name ]:
LolCDE-IN-1

Biological Activity

[Description]:

LolCDE-IN-1 is an inhibitor of the Lol proteins (LolCDE) complex, with antibacterial activity[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

Bacterial

[In Vitro]

LolCDE-IN-1 (compound 2) inhibits the function of the LolCDE complex, which is required for transport of lipoproteins to the outer membrane[1]. LolCDE-IN-1 inhibits E. coli ATCC 25922 and E. coli ATCC 25922 ΔtolCwith MIC with 8 μg/ml and 0.125 μg/ml[1]. LolCDE-IN-1 inhibits bacterial growth by targeting LolCDE to block lipoprotein transport to the outer membrane[1].

[References]

[1]. Nayar AS, et al. Novel antibacterial targets and compounds revealed by a high-throughput cell wall reporter assay. J Bacteriol. 2015 May;197(10):1726-34.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₁₆FN₃O

[ Molecular Weight ]:
345.37

LolCDE-IN-1

Names

Biological Activity

Chemical & Physical Properties

Related Compounds