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LNP023

Names

[ CAS No. ]:
1644670-37-0

[ Name ]:
LNP023

[Synonym ]:
MFCD32174282

Biological Activity

[Description]:

LNP023 is a highly potent factor B (FB) inhibitor with an IC50 value of 10 nM. LNP023 shows direct, reversible, and high-affinity binding to human FB (KD=7.9 nM)[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Complement System
Research Areas >> Inflammation/Immunology

[References]

[1]. Schubart A, et al. Small-molecule factor B inhibitor for the treatment of complement-mediated diseases. Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):7926-7931.

Chemical & Physical Properties

[ Molecular Formula ]:
C25H30N2O4

[ Molecular Weight ]:
422.52

Safety Information

[ Hazard Codes ]:
Xn

Related Compounds