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Neotame

Names

[ CAS No. ]:
165450-17-9

[ Name ]:
Neotame

[Synonym ]:
Methyl N-(3,3-dimethylbutyl)-L-α-aspartyl-L-phenylalaninate
UNII-VJ597D52EX
(3S)-3-(3,3-dimethylbutylamino)-4-[[(2S)-1-methoxy-1-oxo-3-phenylpropan-2-yl]amino]-4-oxobutanoic acid
(3S,4E)-3-[(3,3-Dimethylbutyl)amino]-4-hydroxy-4-{[(2S)-1-methoxy-1-oxo-3-phenyl-2-propanyl]imino}butanoic acid
L-Phenylalanine, N-[(2S)-3-carboxy-2-[(3,3-dimethylbutyl)amino]-1-hydroxypropylidene]-, methyl ester, (E)-
Neotame
Methyl N-(3,3-dimethylbutyl)-L-α-aspartylphenylalaninate
E961
L-phenylalanine, N-(3,3-dimethylbutyl)-L-α-aspartyl-, methyl ester
N-(3,3-Dimethylbutyl)-L-a-aspartyl-L-phenylalanine Methyl Ester
VJ597D52EX
N-(3,3-dimethylbutyl)-L-aspartyl-L-phenylalanine methyl ester
Phenylalanine, N-(3,3-dimethylbutyl)-L-α-aspartyl-, methyl ester
(S)-3-((3,3-Dimethylbutyl)amino)-4-(((S)-1-methoxy-1-oxo-3-phenylpropan-2-yl)amino)-4-oxobutanoic ac
N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine methyl ester
(S)-3-((3,3-Dimethylbutyl)amino)-4-(((S)-1-methoxy-1-oxo-3-phenylpropan-2-yl)amino)-4-oxobutanoic acid

Biological Activity

[Description]:

Neotame is a derivative of Aspartame and is a low-caloric and high-intensity artificial sweetener that is 7000-13,000 times sweeter than sugar. Neotame is a non-nutritive sweetener and flavor enhancer that can be used in a variety of foods[1][2].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[References]

[1]. Liang Chi, et al. Effects of the Artificial Sweetener Neotame on the Gut Microbiome and Fecal Metabolites in Mice. Molecules. 2018 Feb 9;23(2):367.

[2]. Anuradha Kumari, et al. Stability of Aspartame and Neotame in Pasteurized and In-Bottle Sterilized Flavoured Milk. Food Chem. 2016 Apr 1;196:533-8.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
535.8±60.0 °C at 760 mmHg

[ Melting Point ]:
80.9-83.4ºC

[ Molecular Formula ]:
C20H30N2O5

[ Molecular Weight ]:
378.463

[ Flash Point ]:
277.9±32.9 °C

[ Exact Mass ]:
378.215485

[ PSA ]:
104.73000

[ LogP ]:
4.73

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.530

MSDS

Safety Information

[ Safety Phrases ]:
24/25

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2924299090

Synthetic Route

Precursor & DownStream

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%


Related Compounds