<Suppliers Price>

S 18886

Names

[ CAS No. ]:
165538-40-9

[ Name ]:
S 18886

[Synonym ]:
Terutroban [INN]
UNII-A6WX9391D8
terutroban
3-{6-[(4-chlorophenylsulphonyl)amino]-2-methyl-5,6,7,8-tetrahydronaphth-1-yl}-propionic acid

Biological Activity

[Description]:

Terutroban is a thromboxane-prostaglandin receptor antagonist.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor
Research Areas >> Cardiovascular Disease

[References]

[1]. De La Cruz JP, et al. Effects of terutroban, a thromboxane/prostaglandin endoperoxide receptor antagonist, on retinal vascularity in diabetic rats. Diabetes Metab Res Rev. 2012 Feb;28(2):132-138.

[2]. Bots ML, et al. Thromboxane prostaglandin receptor antagonist and carotid atherosclerosis progression in patients with cerebrovascular disease of ischemic origin: a randomized controlled trial. Stroke. 2014 Aug;45(8):2348-2353.

[3]. Lesault PF, et al. Daily administration of the TP receptor antagonist terutroban improved endothelial function in high-cardiovascular-risk patients with atherosclerosis. Br J Clin Pharmacol.2011 Jun;71(6):844-851.


[Related Small Molecules]

Dinoprostone | Prostaglandin E1 | E7046 | ONO-AE3-208 | PF 04418948 | Fevipiprant | grapiprant | TG6-10-1 | Taprenepag | GW 627368 | MRE-269 | Ramatroban | AH 6809 | Laropiprant | AZD1981

Chemical & Physical Properties

[ Density]:
1.389g/cm3

[ Boiling Point ]:
591.818ºC at 760 mmHg

[ Molecular Formula ]:
C20H22ClNO4S

[ Molecular Weight ]:
407.91100

[ Flash Point ]:
311.721ºC

[ Exact Mass ]:
407.09600

[ PSA ]:
91.85000

[ LogP ]:
4.97310

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.637

[ Storage condition ]:
2-8℃

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ RIDADR ]:
NONH for all modes of transport

Related Compounds