O4I2

Names

[ Name ]:
O4I2

[Synonym ]:
Ethyl 2-[(4-chlorophenyl)amino]-1,3-thiazole-4-carboxylate
ETHYL 2-(4-CHLOROPHENYLAMINO)-4-THIAZOLECARBOXYLATE
4-Thiazolecarboxylic acid, 2-[(4-chlorophenyl)amino]-, ethyl ester
O4I2

Biological Activity

[Description]:

O4I2 is a potent Oct3/4 inducer in various human cell lines including human fibroblasts.Target: Oct3/4O4I2 activates Oct3/4 in HEK293 and embryonal NCCIT cells, and also in Oct-deficient HeLa and terminally differentiated human fibroblasts. O4I2 activates also other pluripotencyassociatedgenes such as Lin28 and Nanog in a drug-like manner. O4I2 shows high activity in enforcing Oct3/4 expression. O4I2 activates Oct3/4 on the transcriptional and translational level in human fibroblasts. O4I2 promotes the expression of pluripotency-associated genes as analyzed by qRT-PCR in human neonatal foreskin fibroblasts (HFFs). O4I2 markedly stimulates Oct3/4 even at 5 μM after 72 h treatment on the translational level.

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> Oct3/4

Research Areas >> Others

[References]

[1]. Cheng X, et al. Ethyl 2-((4-Chlorophenyl)amino)thiazole-4-carboxylate and Derivatives Are Potent Inducers of Oct3/4. J Med Chem. 2015 Aug 13;58(15):5742-5750.

[Related Small Molecules]

OAC-2 | O4I1 | OAC1

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
408.1±51.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₂H₁₁ClN₂O₂S

[ Molecular Weight ]:
282.746

[ Flash Point ]:
200.6±30.4 °C

[ Exact Mass ]:
282.022980

[ PSA ]:
79.46000

[ LogP ]:
3.83

[ Appearance of Characters ]:
light yellow solid

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.637

[ Storage condition ]:
-20℃

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2934100090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2934100090

[ Summary ]:
2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%