Benzimidamide hydrochloride

Names

[ Name ]:
Benzimidamide hydrochloride

[Synonym ]:
BENZAMIDE HCL H2O
benzenecarboximidamide hydrochloride
EINECS 216-795-4
benzamidinium chloride
benzamidine-hydrochloride
Benzamidine hydrochloride
BENZAMIDINE HCL
2-phenylamidine hydrochloride
Benzenecarboximidamide hydrochloride (1:1)
benzamidine hydroxychloride
Benzamidine hydrochl
MFCD00013025
Additive Screening
Benzamidine monohydrochloride
AMIDINOBENZENE HYDROCHLORIDE
amidinobenzenehydrochloride
Benzamidin Hydrochloride
Amidinobenzene hydrochloride (1:1)
Benzenecarboximidamide, hydrochloride (1:1)
Benzimidamide hydrochloride
phenyl amidine hydrochloride

Biological Activity

[Description]:

Benzamidine hydrochloride is an reversible competitive inhibitor of trypsin-like serine proteases, with Kis of 97 µM, 21 µM, 20 µM and 110 µM for uPA, trypsin, tryptase and factor Xa, respectively[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease

Research Areas >> Cancer

[Target]

Ki: 97 µM (uPA), 21 µM (trypsin), 20 µM (tryptase), 110 µM (factor Xa)[1]

[In Vitro]

Benzamidine hydrochloride has weak inhibition for tPA and thrombin, with Kis of 750 µM and 320 µM, respectively[1].

[References]

[1]. Tanizawa K, et al. Proteolytic enzymes. VI. Aromatic amidines as competitive inhibitors of trypsin. J Biochem. 1971 May;69(5):893-9.

[2]. Katz BA, et al. Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator. Chem Biol. 2000 Apr;7(4):299-312.

Chemical & Physical Properties

[ Density]:
1.09 g/cm3

[ Boiling Point ]:
332.9ºC at 760 mmHg

[ Melting Point ]:
86-88 °C(lit.)

[ Molecular Formula ]:
C₇H₉ClN₂

[ Molecular Weight ]:
156.613

[ Flash Point ]:
155.1ºC

[ Exact Mass ]:
156.045425

[ PSA ]:
49.87000

[ LogP ]:
2.57270

[ Vapour Pressure ]:
5.63E-05mmHg at 25°C

[ Water Solubility ]:
soluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CV6260000

CHEMICAL NAME :: Benzamidine, hydrochloride

CAS REGISTRY NUMBER :: 1670-14-0

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C7-H8-N2.Cl-H

MOLECULAR WEIGHT :: 156.63

WISWESSER LINE NOTATION :: ZYR&UM &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 580 mg/kg

TOXIC EFFECTS :: Brain and Coverings - meningeal changes Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes

REFERENCE :: BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 20,1045,1979

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
CV6260000

[ HS Code ]:
2925290090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2925290090

[ Summary ]:
2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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