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R-96544 hydrochloride

Names

[ CAS No. ]:
167144-79-8

[ Name ]:
R-96544 hydrochloride

Biological Activity

[Description]:

R-96544 (free base) is a potent, selective and competitive 5-HT2 receptor antagonist. R-96544 (free base) inhibits platelet aggregation induced by serotonin, and inhibits 5-HT2A receptor-mediated contraction of guinea pig trachea[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor
Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[References]

[1]. Ogawa T,et al. Pharmacological profiles of R-96544, the active form of a novel 5-HT2A receptor antagonist R-102444. Eur J Pharmacol. 2002;457(2-3):107-114. doi:10.1016/s0014-2999(02)02654-7  

Chemical & Physical Properties

[ Boiling Point ]:
484.5ºC at 760mmHg

[ Molecular Formula ]:
C22H29NO3

[ Molecular Weight ]:
355.47

[ Flash Point ]:
246.8ºC

[ Exact Mass ]:
391.19100

[ PSA ]:
41.93000

[ LogP ]:
4.05420

[ Vapour Pressure ]:
3.35E-10mmHg at 25°C

Related Compounds