1H-Pyrrole-2,5-dione,3-b-D-ribofuranosyl-

Names

[ CAS No. ]:
16755-07-0

[ Name ]:
1H-Pyrrole-2,5-dione,3-b-D-ribofuranosyl-

[Synonym ]:
SHOWDOMYCIN
Showdomycin
showndomycin

Biological Activity

[Description]:

Showdomycin is an antibiotic produced by IM-2-induced in Streptomyces[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Hashimoto K, et al. IM-2, a butyrolactone autoregulator, induces production of several nucleoside antibiotics in Streptomyces sp. FRI-5[J]. Journal of fermentation and bioengineering, 1992, 73(6): 449-455.

Chemical & Physical Properties

[ Density]:
1.697g/cm3

[ Boiling Point ]:
562.4ºC at 760mmHg

[ Molecular Formula ]:
C₉H₁₁NO₆

[ Molecular Weight ]:
229.18700

[ Flash Point ]:
293.9ºC

[ Exact Mass ]:
229.05900

[ PSA ]:
116.09000

[ Vapour Pressure ]:
5.47E-15mmHg at 25°C

[ Index of Refraction ]:
1.648

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ON6200000

CHEMICAL NAME :: Maleimide, 2-beta-D-ribofuranosyl-

CAS REGISTRY NUMBER :: 16755-07-0

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C9-H11-N-O6

MOLECULAR WEIGHT :: 229.21

WISWESSER LINE NOTATION :: T5VMVJ D- BT5OTJ CQ DQ E1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAJAAA Journal of Antibiotics, Series A. (Tokyo, Japan) V.6-20, 1953-67. For publisher information, see JANTAJ. Volume(issue)/page/year: 17,148,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 18 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAJAAA Journal of Antibiotics, Series A. (Tokyo, Japan) V.6-20, 1953-67. For publisher information, see JANTAJ. Volume(issue)/page/year: 17,148,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 110 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 2,1443,1978