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RS 39604 hydrochloride

Names

[ CAS No. ]:
167710-87-4

[ Name ]:
RS 39604 hydrochloride

[Synonym ]:
GNF-Pf-5475

Biological Activity

[Description]:

RS 39604 is a potent, selective, and orally active 5-HT4 receptor antagonist with a pKi of 9.1 in guinea pig striatal membranes. RS 39604 displays a low affinity (pKi<6.5) for 5-HT1A, 5-HT2C, 5-HT3, α1c, D1, D2, M1, M2, AT1, B1 and opioid mu receptors and moderate affinity for δ1, (pKi=6.8) and δ2 (pKi=7.8) sites[1].

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor
Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[Target]

5-HT4 Receptor:9.1 (pKi)


[References]

[1]. Hegde SS, et al. RS 39604: a potent, selective and orally active 5-HT4 receptor antagonist. Br J Pharmacol. 1995;115(6):1087-1095.

Chemical & Physical Properties

[ Boiling Point ]:
746.9ºC at 760 mmHg

[ Molecular Formula ]:
C26H37Cl2N3O6S

[ Molecular Weight ]:
590.55900

[ Flash Point ]:
405.5ºC

[ Exact Mass ]:
589.17800

[ PSA ]:
128.57000

[ LogP ]:
6.53530

[ Vapour Pressure ]:
1.25E-22mmHg at 25°C

Related Compounds