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1H-Indole-2-carboxamide, N-[(3R)-1-(2-fluorophenyl)-3,4,6,7-tetrahydro-4-oxopyrrolo[3,2,1-jk][1,4]benzodiazepin-3-yl]-

Names

[ CAS No. ]:
167820-10-2

[ Name ]:
1H-Indole-2-carboxamide, N-[(3R)-1-(2-fluorophenyl)-3,4,6,7-tetrahydro-4-oxopyrrolo[3,2,1-jk][1,4]benzodiazepin-3-yl]-

[Synonym ]:
N-[(3R)-1-(2-Fluorophenyl)-4-oxo-3,4,6,7-tetrahydro[1,4]diazepino[6,7,1-hi]indol-3-yl]-1H-indole-2-carboxamide
1H-Indole-2-carboxamide, N-[(3R)-1-(2-fluorophenyl)-3,4,6,7-tetrahydro-4-oxo[1,4]diazepino[6,7,1-hi]indol-3-yl]-
1H-Indole-2-carboxamide, N-[(3R)-1-(2-fluorophenyl)-3,4,6,7-tetrahydro-4-oxopyrrolo[3,2,1-jk][1,4]benzodiazepin-3-yl]-

Biological Activity

[Description]:

CHEMBL333994 is a potent and orally effective Cholecystokinin A (CCK-A) antagonist, with an IC50 of 0.67 nM.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Cholecystokinin Receptor
Research Areas >> Others

[Target]

IC50: 0.67 nM(CCK-A)[1].


[References]

[1]. Satoh Y, et al. Studies on a novel, potent and orally effective cholecystokinin A antagonist, FK-480. Synthesis and structure-activity relationships of FK-480 and related compounds. Chem Pharm Bull (Tokyo). 1994 Oct;42(10):2071-83.


[Related Small Molecules]

Caerulein ammonium salt | Gastrin I (human) | Nastorazepide | Loxiglumide | Proglumide | Sograzepide | Tarazepide | CCK-A receptor inhibitor 1 | CCK-B Receptor Antagonist 1 | Gastrin/CCK antagonist 1 | GI 181771 | Mini Gastrin I, human | SR 146131

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
759.3±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C26H19FN4O2

[ Molecular Weight ]:
438.453

[ Flash Point ]:
413.0±32.9 °C

[ Exact Mass ]:
438.149200

[ LogP ]:
3.56

[ Vapour Pressure ]:
0.0±2.6 mmHg at 25°C

[ Index of Refraction ]:
1.740

Related Compounds