AZ Dyrk1B 33

Names

[ CAS No. ]:
1679330-37-0

[ Name ]:
AZ Dyrk1B 33

Biological Activity

[Description]:

AZ-Dyrk1B-33 is a potent and selective Dyrk1B kinase inhibitor, with an IC50 of 7 nM[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> DYRK

Research Areas >> Metabolic Disease

[Target]

IC50: 7 nM (Dyrk1B)[1]

[In Vitro]

AZ-Dyrk1B-33 shows inhibition of phosphorylation of Dyrk pS421 in cells with an IC50 of 0.192 μM[1]. AZ-Dyrk1B-33 shows no effect in sensitization[1].

[References]

[1]. Kettle JG, et al. Discovery and optimization of a novel series of Dyrk1B kinase inhibitors to explore a MEK resistance hypothesis. J Med Chem. 2015 Mar 26;58(6):2834-44.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₁₆N₄

[ Molecular Weight ]:
300.36

AZ Dyrk1B 33

Names

Biological Activity

Chemical & Physical Properties

Related Compounds