AIDA

Names

[ Name ]:
AIDA

[Synonym ]:
1-AMINOINDAN-1,5-DICARBOXYLIC ACID,UPF 5 23
MFCD00672638
(R,S)-1-Aminoindane-1,5
Valerenic acid
1-Amino-2,3-dihydro-1H-indene-1,5-dicarboxylic acid,1-Aminoindan-1,5-dicarboxylic acid

Biological Activity

[Description]:

UPF-523 (AIDA), a rigid (carboxyphenyl) glycine derivative, is a relatively potent and selective antagonist of group I metabotropic glutamate receptors (mGlu1a) with an IC50 of 214 μM. But UPF-523 has no effect on group II (mGlu2), group III (mGlu4) receptors or ionotropic glutamate receptors. UPF-523 has the potential for the research of the acute arthritis[1][2].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> GPCR/G Protein >> mGluR

[Target]

mGluR1a:214 μM (IC50)

[In Vivo]

UPF-523 (0.18 mg/kg; i.p.; 0.5 ml per 100 g) results in a final concentration of 100–150 mM which is below an IC50 of 214 mM[1]. Animal Model: Naive male hooded Lister rats (320–350 g)[1] Dosage: 0.18 mg/kg Administration: I.p.; 0.5 ml per 100 g Result: Showed no gross motor abnormalities and normal righting reflexes.

[References]

[1]. Nielsen KS, et al. Class I mGlu receptor antagonist 1-aminoindan-1,5-dicarboxylic acid blocks contextual but not cue conditioning in rats. Eur J Pharmacol. 1997;326(2-3):105-108.

[2]. Zhang LP, et al. The Role of Type 1 Metabotropic Glutamate Receptors in the Generation of Dorsal Root Reflexes Induced by Acute Arthritis or the Spinal Infusion of 4-Aminopyridine in the Anesthetized Rat. J Pain. 2000;1(2):151-161.

Chemical & Physical Properties

[ Density]:
1.481 g/cm3

[ Boiling Point ]:
470.4ºC at 760 mmHg

[ Molecular Formula ]:
C₁₁H₁₁NO₄

[ Molecular Weight ]:
221.20900

[ Flash Point ]:
238.3ºC

[ Exact Mass ]:
221.06900

[ PSA ]:
100.62000

[ LogP ]:
1.26990

[ Vapour Pressure ]:
1.19E-09mmHg at 25°C

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S37/39

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2922499990

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

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