Bromoacetamido-PEG8-acid

Names

[ Name ]:
Bromoacetamido-PEG8-acid

[Synonym ]:
6,9,12,15,18,21,24,27-Octaoxa-3-azatriacontan-30-oic acid, 1-bromo-2-oxo-
1-Bromo-2-oxo-6,9,12,15,18,21,24,27-octaoxa-3-azatriacontan-30-oic acid
MFCD27635172

Biological Activity

[Description]:

Bromoacetamido-PEG8-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
671.3±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₄₀BrNO₁₁

[ Molecular Weight ]:
562.446

[ Flash Point ]:
359.8±31.5 °C

[ Exact Mass ]:
561.178467

[ LogP ]:
-2.74

[ Vapour Pressure ]:
0.0±4.4 mmHg at 25°C

[ Index of Refraction ]:
1.486

Bromoacetamido-PEG8-acid

Names

Biological Activity

Chemical & Physical Properties

Related Compounds