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AQ-13 dihydrochloride

Names

[ CAS No. ]:
169815-40-1

[ Name ]:
AQ-13 dihydrochloride

[Synonym ]:
AQ 13
1,3-Propanediamine,N'-(7-chloro-4-quinolinyl)-N,N-diethyl-,dihydrochloride
(N1-(7-Chloroquinolin-4-yl)-3-(N3,N3-diethylamino)propylamine) dihydrochloride

Biological Activity

[Description]:

AQ-13 dihydrochloride is an aminoquinoline antimalarial drug that is effective against chloroquine-resistant strains of Plasmodium falciparum.

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Infection

[In Vivo]

Slight decreases in the PCE/RBC ratio are observed in male and female rats treated with CQ and in females only treated with AQ-13; however, none of these changes is statistically significant[1].

[Animal admin]

Rats[1] Male and female Sprague-Dawley rats are used and are 8-9 weeks of age at the time of dose administration. Micronucleus evaluations are conducted in conjunction with repeatdose toxicity studies. Rats are orally administered AQ-13 or CQ in water. Rats are given a “loading dose” followed by maintenance doses of one-half the loading dose administered 12 hr later and daily thereafter for 6 additional days[1].

[References]

[1]. Riccio ES, et al. Genetic toxicology testing of the antimalarial drugs chloroquine and a new analog, AQ-13. Environ Mol Mutagen. 2001;38(1):69-79.


[Related Small Molecules]

Captisol | Cyclosporin A | H2DCFDA | 0MPTP hydrochloride | GW4869 | Etomoxir | TD139 | Mitoquinone mesylate | GSK2795039 | JC-1 | BAPTA-AM | AP 20187 | Setanaxib (GKT137831) | D-Luciferin | Crotaline

Chemical & Physical Properties

[ Molecular Formula ]:
C16H24Cl3N3

[ Molecular Weight ]:
364.74100

[ Exact Mass ]:
363.10400

[ PSA ]:
28.16000

[ LogP ]:
5.70900

[ Storage condition ]:
2-8℃

Related Compounds