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Zidebactam sodium salt

Names

[ CAS No. ]:
1706777-46-9

[ Name ]:
Zidebactam sodium salt

Biological Activity

[Description]:

Zidebactam sodium salt (WCK-5107 sodium salt) is a potent β-lactamase inhibitor[1]. Zidebactam also is a penicillin-binding protein2 (PBP2) inhibitor with an IC50 of 0.26 μg/mL[2].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Bacterial

[Target]

IC50: 0.26±0.06 μg/mL (P. aeruginosa PAO1 PBP2)[2].


[In Vitro]

Zidebactam sodium salt (WCK-5107 sodium salt) inhibits WT Enterobacteriaceae with a MIC50 of 0.25 mg/L[1].Zidebactam sodium salt (WCK-5107 sodium salt) alone exhibits variable activity when tested against E. coli (MIC50/90 0.12/0.12  mg/L) and Enterobacter spp. (MIC50/90 0.12/0.25  mg/L)[1].

[References]

[1]. Sader HS, et al. WCK 5222 ( cefepime/zidebactam ) antimicrobial activity tested against Gram-negative organisms producing clinically relevant β-lactamases. J Antimicrob Chemother. 2017 Jun 1;72(6):1696-1703.

[2]. Moya B, et al. WCK 5107 (Zidebactam) and WCK 5153 Are Novel Inhibitors of PBP2 Showing Potent "β-Lactam Enhancer" Activity against Pseudomonas aeruginosa, Including Multidrug-Resistant Metallo-β-Lactamase-Producing High-Risk Clones. Antimicrob Agents Chemother. 2017 May 24;61(6).

Chemical & Physical Properties

[ Molecular Formula ]:
C13H20N5NaO7S

[ Molecular Weight ]:
413.38

[ Storage condition ]:
2-8℃

Related Compounds