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oritavancin

Names

[ CAS No. ]:
171099-57-3

[ Name ]:
oritavancin

[Synonym ]:
LY333328
Orbactiv

Biological Activity

[Description]:

Oritavancin (LY 333328) is an orally active glycopeptide antibiotic with activity against gram-positive organisms. Oritavancin shows antibacterial effect against multidrug-resistant S. pneumoniae. Oritavancin inhibits cell wall synthesis and disrupts the membrane potential[1][2].

[Related Catalog]:

Research Areas >> Infection
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Coyle EA, et al. Activity of oritavancin (LY333328), an investigational glycopeptide, compared to that of vancomycin against multidrug-resistant Streptococcus pneumoniae in an in vitro pharmacodynamic model. Antimicrob Agents Chemother. 2001 Mar;45(3):706-9.

[2]. Arhin FF, et al. Effect of polysorbate 80 on oritavancin binding to plastic surfaces: implications for susceptibility testing. Antimicrob Agents Chemother. 2008 May;52(5):1597-603.

Chemical & Physical Properties

[ Molecular Formula ]:
C86H97Cl3N10O26

[ Molecular Weight ]:
1793.10000

[ Exact Mass ]:
1790.56000

[ PSA ]:
560.98000

[ LogP ]:
8.57000

Safety Information

[ Hazard Codes ]:
Xn

Related Compounds