12-epi-TadalafilTadalafil

Names

[ Name ]:
12-epi-TadalafilTadalafil

[Synonym ]:
UNII-E319TQ0B6R
cis-ent-Tadalafil
PYR403
12-epi-TadalafilTadalafil
Tadalafil Impurity 13

[Description]:

cis-Tadalafil is a PDE5 inhibitor (IC50: 0.09 μM). cis-Tadalafil can be used for research of cardiovascular diseases[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)

[Target]

PDE5:0.09 μM (IC50)

[In Vitro]

cis-Tadalafil (Compound 12b) 抑制 PDE5，IC50 为 0.09 μM[1]。

[References]

[ Density]:
1.51±0.1 g/cm3 (20 ºC 760 Torr)

[ Melting Point ]:
295-296 ºC

[ Molecular Formula ]:
C₂₂H₁₉N₃O₄

[ Molecular Weight ]:
389.40

[ Exact Mass ]:
389.13800

[ PSA ]:
74.87000

[ LogP ]:
2.08710

[ Water Solubility ]:
Insuluble (8.6E-3 g/L) (25 ºC)