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NBI-98854

Names

[ CAS No. ]:
171598-74-6

[ Name ]:
NBI-98854

Biological Activity

[Description]:

NBI-98854 is a potent, highly selective, VMAT2 inhibitor that is effective in regulating the levels of dopamine release during nerve communication.IC50 value:Target: VMAT2NBI-98854 completed a Phase I single ascending dose clinical trial in healthy male volunteers in Canada under an approved Clinical Trial Application with Health Canada.This trial showed NBI-98854 to be generally safe and well tolerated.

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Monoamine Transporter
Research Areas >> Neurological Disease

[References]

[1]. NBI-98854 - Vesicular Monoamine Transporter 2 Inhibitor (VMAT2).


[Related Small Molecules]

Reserpine | NBI-98782 | (±)-Tetrabenazine | Radafaxine (hydrochloride) | Vanilpyruvic acid

Chemical & Physical Properties

[ Melting Point ]:
167-170°C

[ Molecular Formula ]:
C19H29NO3

[ Molecular Weight ]:
319.44

[ Storage condition ]:
Refrigerator

Related Compounds