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4-(3-bromoanilino)-6,7-diethoxyquinazoline

Names

[ CAS No. ]:
171745-13-4

[ Name ]:
4-(3-bromoanilino)-6,7-diethoxyquinazoline

[Synonym ]:
compound 56
N-(3-Bromophenyl)-6,7-diethoxyquinazolin-4-amine
4-(3'-bromoanilino)-6,7-diethoxyquinazoline
4-(3-bromoanilino)-6,7-diethoxyquinazoline
4-quinazolinamine, N-(3-bromophenyl)-6,7-diethoxy-
N-(3-Bromophenyl)-6,7-diethoxy-4-quinazolinamine
4-[(3-bromophenyl)amino]-6,7-diethoxyquinazoline
(3-Bromophenyl)-(6,7-diethoxyquinazolin-4-yl)-amine
YXOXHAUUTIOBDA-UHFFFAOYSA

Biological Activity

[Description]:

EGFR-IN-80 (compound 30) is an EGFR inhibitor with a pIC50 of 10.6[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> JAK/STAT Signaling >> EGFR
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

[Target]

EGFR:10.6 (pIC50)


[References]

[1]. Farhan Ahmad Pasha, et al. In silico QSAR studies of anilinoquinolines as EGFR inhibitors. J Mol Model. 2010 Feb;16(2):263-77.  

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
492.6±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C18H18BrN3O2

[ Molecular Weight ]:
388.26

[ Flash Point ]:
251.7±28.7 °C

[ Exact Mass ]:
387.058228

[ PSA ]:
56.27000

[ LogP ]:
5.14

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.652

Safety Information

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds