2-Hydroxy-3-methylanthraquinone

Names

[ Name ]:
2-Hydroxy-3-methylanthraquinone

[Synonym ]:
2-Hydroxy-3-methylanthraquinone
3-hydroxy-2-methylanthraquinone
2-Hydroxy-3-methyl-9,10-anthraquinone
W1213
9,10-Anthracenedione, 2-hydroxy-3-methyl-
3-hydroxy-2-methyl-9,10-anthraquinone
2-hydroxy-3-methyl-anthracene-9,10-dione
2-Hydroxy-3-methyl-anthrachinon
3-Oxy-2-methyl-anthrachinon

Biological Activity

[Description]:

2-Hydroxy-3-methylanthraquinone (compound 1) is a natural compound isolated from a water extract of Hedyotis diffusa WILLD. 2-Hydroxy-3-methylanthraquinone shows inhibitory activity against protein tyrosine kinases v-src and pp60src, and induces growth arrest and apoptosis in the HepG2 cancer cells[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Src

[Target]

55 μM (HepG2 cells)[1]

[References]

[1]. Shi Y, Wang CH, Gong XG. Apoptosis-inducing effects of two anthraquinones from Hedyotis diffusa WILLD. Biol Pharm Bull. 2008;31(6):1075-1078.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
439.7±34.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₅H₁₀O₃

[ Molecular Weight ]:
238.238

[ Flash Point ]:
233.8±22.2 °C

[ Exact Mass ]:
238.062988

[ PSA ]:
54.37000

[ LogP ]:
3.83

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.676

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2914690090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914690090

[ Summary ]:
2914690090 other quinones。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%