Azido-PEG3-C-Boc

Names

[ Name ]:
Azido-PEG3-C-Boc

[Synonym ]:
tert-butyl 2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)acetate
tert-butyl 2-[2-(2-(2-azidoethoxy)ethoxy)ethoxy]acetate
tert-butyl 11-azido-3,6,9-trioxaundecanoate

Biological Activity

[Description]:

Azido-PEG3-C-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₂H₂₃N₃O₅

[ Molecular Weight ]:
289.32800

[ Exact Mass ]:
289.16400

[ PSA ]:
103.74000

[ LogP ]:
1.14096

Azido-PEG3-C-Boc

Names

Biological Activity

Chemical & Physical Properties

Related Compounds