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Bromoacetamide-PEG3-C1-acid

Names

[ CAS No. ]:
173323-22-3

[ Name ]:
Bromoacetamide-PEG3-C1-acid

[Synonym ]:
14-Bromo-13-oxo-3,6,9-trioxa-12-azatetradecan-1-oic acid
Tatdabo
OR8462

Biological Activity

[Description]:

Bromoacetamide-PEG3-C1-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Density]:
1.449g/cm3

[ Boiling Point ]:
539.5ºC at 760mmHg

[ Molecular Formula ]:
C10H18BrNO6

[ Molecular Weight ]:
328.15700

[ Flash Point ]:
280.1ºC

[ Exact Mass ]:
327.03200

[ PSA ]:
97.58000

[ LogP ]:
0.47220

[ Vapour Pressure ]:
4.51E-13mmHg at 25°C

[ Index of Refraction ]:
1.499

Related Compounds