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Andrastin A

Names

[ CAS No. ]:
174232-42-9

[ Name ]:
Andrastin A

Biological Activity

[Description]:

Andrastin A meroterpenoid compound, is a farnesyltransferase inhibitor. Andrastin A inhibits the efflux of anticancer compounds from multidrug-resistant cancer cells. Andrastin A can be isolated from Penicillium species[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Farnesyl Transferase

[References]

[1]. Nielsen KF, et al. Andrastins A-D, Penicillium roqueforti Metabolites consistently produced in blue-mold-ripened cheese. J Agric Food Chem. 2005 Apr 20;53(8):2908-13.  

[2]. Rojas-Aedo JF, et al. The Biosynthetic Gene Cluster for Andrastin A in Penicillium roqueforti. Front Microbiol. 2017 May 5;8:813.  

Chemical & Physical Properties

[ Density]:
1.19g/cm3

[ Boiling Point ]:
560.3ºC at 760 mmHg

[ Molecular Formula ]:
C28H38O7

[ Molecular Weight ]:
486.59700

[ Flash Point ]:
236.1ºC

[ Exact Mass ]:
486.26200

[ PSA ]:
103.81000

[ LogP ]:
3.86940

[ Vapour Pressure ]:
1.39E-12mmHg at 25°C

[ Index of Refraction ]:
1.54

Related Compounds