P-TOLYL-BETA-D-GLUCURONIDE

Names

[ Name ]:
P-TOLYL-BETA-D-GLUCURONIDE

[Synonym ]:
p-Tolyl-|A-D-glucuronide
4-Methylphenol glucuronide
p-methylphenyl glucuronide
p-Cresol glucuronide
p-Tolyl-|A-D-glucuronic acid

Biological Activity

[Description]:

p-Cresol glucuronide, a metabolite of p-cresol, is a prototype protein-bound uremic toxin. p-Cresol glucuronide is associated with chronic kidney disease (CKD)[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

[References]

[1]. Liabeuf S, et al. Does p-cresylglucuronide have the same impact on mortality as other protein-bound uremic toxins? PLoS One. 2013 Jun 24;8(6):e67168.

Chemical & Physical Properties

[ Density]:
1.524g/cm3

[ Boiling Point ]:
549.7ºC at 760mmHg

[ Molecular Formula ]:
C₁₃H₁₆O₇

[ Molecular Weight ]:
284.26200

[ Flash Point ]:
211.6ºC

[ Exact Mass ]:
284.09000

[ PSA ]:
116.45000

[ Vapour Pressure ]:
6.42E-13mmHg at 25°C

[ Index of Refraction ]:
1.633

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Studies of catalysis by -glucuronidase. The effect of structure on the rate of hydrolysis of substituted phenyl- -d-glucopyranosiduronic acids.

J. Biol. Chem. 247 , 2650-2656, (1972)

HPLC of phenolic glucuronides in isolated rabbit hepatocytes. Sawa, M., et al.

Chromatographia 1988 , 247-250

Rates of hydrolysis of substituted phenyl β-D-gulcuronides by β-glucuronidase. Watabe, T., et al.

Chem. Pharm. Bull. 18 , 414-415, (1970)