Dropropizine

Names

[ Name ]:
Dropropizine

[Synonym ]:
Dropropizine
1,2-Propanediol, 3-(4-phenyl-1-piperazinyl)-
Tussilex
1-(2,3-Dihydroxypropyl)-4-phenylpiperazine
(+-)-Dropropizine
Ribex
EINECS 241-683-7
Larylin
Ditustat
1-Phenyl-4-(2,3-dihydroxypropyl)piperazine
1-Phenyl-4-(2,3-dihydroxypropyl)diethylenediamine
Dipropizine
MFCD00079124
3-(4-phenylpiperazin-1-yl)propane-1,2-diol
Dopropizin
Catabex
levodropropizine
3-(4-Phenyl-1-piperazinyl)-1,2-propanediol
Katril

Biological Activity

[Description]:

Dropropizine is a racemic non-opiate antitussive agent which has been used clinically for many years.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
412.7±34.0 °C at 760 mmHg

[ Melting Point ]:
105-108ºC

[ Molecular Formula ]:
C₁₃H₂₀N₂O₂

[ Molecular Weight ]:
236.310

[ Flash Point ]:
220.9±24.3 °C

[ Exact Mass ]:
236.152481

[ PSA ]:
46.94000

[ LogP ]:
0.46

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.577

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TZ1074800

CHEMICAL NAME :: 1,2-Propanediol, 3-(4-phenyl-1-piperazinyl)-

CAS REGISTRY NUMBER :: 17692-31-8

LAST UPDATED :: 199712

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C13-H20-N2-O2

MOLECULAR WEIGHT :: 236.35

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3163649

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3163649

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 620 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4372958

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 720 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4372958

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
TZ1074800

[ HS Code ]:
2933599090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Efficacy and tolerability of levodropropizine and dropropizine in children with non-productive cough.

J. Int. Med. Res. 23(3) , 175-83, (1995)

The antitussive efficacy and tolerability of dropropizine and of its enantiomer levodropropizine were evaluated in children with non-productive cough; 258 were evaluable for tolerability and 254 for e...

Efficacy of levodropropizine in pediatric cough.

Pulm. Pharmacol. Ther. 25(5) , 337-42, (2012)

Cough in children is among the most common problems managed by pediatricians, and occurs more frequently in preschool than in older children. Most acute episodes of cough are due to viral upper respir...

Studies on the human metabolism and the toxicologic detection of the cough suppressant dropropizine in urine using gas chromatography-mass spectrometry.

Ther. Drug Monit. 26(4) , 441-9, (2004)

Studies are described on the metabolism and the toxicologic analysis of the nonopioid cough suppressant dropropizine [R,S-3-(4-phenyl-1-piperazinyl)1,2-propandiol, DRO] in human urine using gas chroma...