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LY88074

Names

[ CAS No. ]:
177744-96-6

[ Name ]:
LY88074

Biological Activity

[Description]:

LY88074 (Compound 88074) is a Raloxifene analog lacking the basic side chain. Raloxifene is a selective estrogen receptor modulator, and reduces fracture risk at least in part by improving the mechanical properties of bone in a cell- and estrogen receptor-independent manner[1].

[Related Catalog]:

Research Areas >> Endocrinology
Signaling Pathways >> Others >> Others

[In Vitro]

Removal of the aminoethylpiperdine moiety, as in LY88074 (Compound 88074), reduces bone binding, compared to Raloxifene. The interaction of LY88074 with collagen matrix, although significant, is less than the interaction found with Raloxifene[1].

[References]

[1]. Bivi N, et al. Structural features underlying raloxifene's biophysical interaction with bone matrix. Bioorg Med Chem. 2016 Feb 15;24(4):759-67.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H14O4S

[ Molecular Weight ]:
346.39900

[ Exact Mass ]:
346.06600

[ PSA ]:
85.77000

[ LogP ]:
5.21050

Related Compounds