H-D-Asp-OH

Names

[ Name ]:
H-D-Asp-OH

[Synonym ]:
δ-aspartic acid
D(-)-Aspartic acid
d-Asp
QVYZ1VQ &&D or R Form
(-)-Aspartic acid
(2R)-2-Aminosuccinic acid
Aspartic acid,D
D-Aspartate
MFCD00063081
(2R)-2-aminobutanedioic acid
hydrogen D-aspartate
(R)-2-Aminosuccinic acid
(R)-Aminosuccinic Acid
D-Asparaginic Acid
(R)-(−)-Aminosuccinic acid
D-(-)-Aspartic acid
(R)-(−)-Aminosuccinic acid,(R)-2-Aminosuccinic acid
Acide (2R)-2-aminosuccinique
aspartic acid D-form
D-Asparticacid
EINECS 217-234-6
Aspartic acid, D-
D-Aspartic acid
H-D-Asp-OH
L-Ornithine L-Aspartate Impurity 1

Biological Activity

[Description]:

(-)-Aspartic acid is an endogenous NMDA receptor agonist.

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

Signaling Pathways >> Neuronal Signaling >> iGluR

Research Areas >> Neurological Disease

Natural Products >> Others

[Target]

Human Endogenous Metabolite

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
264.1±30.0 °C at 760 mmHg

[ Melting Point ]:
300ºC

[ Molecular Formula ]:
C₄H₇NO₄

[ Molecular Weight ]:
133.103

[ Flash Point ]:
113.5±24.6 °C

[ Exact Mass ]:
133.037506

[ PSA ]:
100.62000

[ LogP ]:
-0.67

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.531

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CI9097500

CHEMICAL NAME :: D-Aspartic acid

CAS REGISTRY NUMBER :: 1783-96-6

BEILSTEIN REFERENCE NO. :: 1723529

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C4-H7-N-O4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6063 mg/kg/7D-C

TOXIC EFFECTS :: Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Metabolism (Intermediary) - other proteins

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 32,738,1982

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
CI9097500

[ HS Code ]:
29224995

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

Articles

Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter.

Nature 445 , 387-93, (2007)

Secondary transporters are integral membrane proteins that catalyse the movement of substrate molecules across the lipid bilayer by coupling substrate transport to one or more ion gradients, thereby p...

Oral administration of D-aspartate, but not L-aspartate, depresses rectal temperature and alters plasma metabolites in chicks.

Life Sci. 109(1) , 65-71, (2014)

L-Aspartate (L-Asp) and D-aspartate (D-Asp) are physiologically important amino acids in mammals and birds. However, the functions of these amino acids have not yet been fully understood. In this stud...

Okibacterium endophyticum sp. nov., a novel endophytic actinobacterium isolated from roots of Salsola affinis C. A. Mey.

Antonie van Leeuwenhoek 107(3) , 835-43, (2015)

A white bacterial strain, designated EGI 650022(T), was isolated from the roots of Salsola affinis C. A. Mey, collected from Urumqi City, Xinjiang, north-western China. The strain was found to be aero...