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Caspase-1 Inhibitor II

Names

[ CAS No. ]:
178603-78-6

[ Name ]:
Caspase-1 Inhibitor II

[Synonym ]:
Ac-YVAD-cmk
N-Ac-Tyr-Val-Ala-Asp-CMK
AC-TYR-VAL-ALA-ASP-CHLOROMETHYLKETONE
AC-YVAD-CHLOROMETHYLKETONE
AC-TYR-VAL-ALA-ASP-CH2CL
AC-TYR-VAL-ALA-ASP-CMK
N-Acetyl-L-tyrosyl-L-valyl-N-[(2S)-1-carboxy-4-chloro-3-oxobutan-2-yl]-L-alaninamide
PASE-1 INHIBITOR II
ICE INHIBITOR II
IL-1BETA CONVERTING ENZYME INHIBITOR II
L-Alaninamide, N-acetyl-L-tyrosyl-L-valyl-N-[(1S)-1-(carboxymethyl)-3-chloro-2-oxopropyl]-
AC-TYR-ALA-ASP-CHLOROMETHYLKETONE
N-Acetyl-L-tyrosyl-L-valyl-N-[(2S)-1-carboxy-4-chloro-3-oxo-2-butanyl]-L-alaninamide

Biological Activity

[Description]:

Ac-YVAD-cmk (Caspase-1 Inhibitor II) is a selective caspase-1 (IL-1beta converting enzyme, ICE)) inhibitor with neuroprotective and anti-inflammatory effects. Ac-YVAD-cmk effectively suppresses the expression of IL-1β and IL-18. Ac-YVAD-cmk inhibits pyroptosis in many diseases[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Caspase
Research Areas >> Inflammation/Immunology

[Target]

Caspase-1


[In Vitro]

Ac-YVAD-cmk (40 μM or 80 μM) reduces the expression of IL-1β and IL-18 in activated microglia in vitro[2].

[In Vivo]

Ac-YVAD-cmk treatment (1 μg/rats; SD rat; injected into the left lateral ventricle) significantly decreases the protein levels of caspase-1 (p20), mature IL-1β/IL-18 compared with the ICH group[2]. Ac-YVAD-cmk (rats with ac-YVAD-cmk at a dose of 12.5 μmol/kg) significantly reduces mortality from 83 to 33% using Log Rank analysis[3].

[References]

[1]. Wang F, et al. Alcohol accumulation promotes esophagitis via pyroptosis activation. Int J Biol Sci. 2018;14(10):1245-1255. Published 2018 Jul 13.

[2]. Liang H, et al. Ac-YVAD-cmk improves neurological function by inhibiting caspase-1-mediated inflammatory response in the intracerebral hemorrhage of rats. Int Immunopharmacol. 2019;75:105771.

[3]. Mathiak G, et al. Caspase-1-inhibitor ac-YVAD-cmk reduces LPS-lethality in rats without affecting haematology or cytokine responses. Br J Pharmacol. 2000;131(3):383-386.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
969.1±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C24H33ClN4O8

[ Molecular Weight ]:
540.994

[ Flash Point ]:
539.9±34.3 °C

[ Exact Mass ]:
540.198669

[ PSA ]:
191.00000

[ LogP ]:
1.93

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.554

[ Storage condition ]:
-20°C

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
AY3079566

Related Compounds