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Calciseptin

Names

[ CAS No. ]:
178805-91-9

[ Name ]:
Calciseptin

Biological Activity

[Description]:

Calciseptine, a natural?neurotoxin?isolated from the black mamba Dendroaspis p. polylepis venom. Calciseptine consists of 60 amino acids with four disulfide bonds. Calciseptine specifically blocks L-type?calcium channel[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel
Research Areas >> Others

[Target]

L-type calcium channel:15 nM (IC50)


[References]

[1]. H Schweitz, et al. Calcicludine, a venom peptide of the Kunitz-type protease inhibitor family, is a potent blocker of high-threshold Ca2+ channels with a high affinity for L-type channels in cerebellar granule neurons. Proc Natl Acad Sci U S A. 1994 Feb 1; 91(3): 878–882.  

Chemical & Physical Properties

[ Storage condition ]:
?20°C

Related Compounds