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PDE4-IN-4

Names

[ CAS No. ]:
1793069-00-7

[ Name ]:
PDE4-IN-4

Biological Activity

[Description]:

PDE4-IN-4 is a dual M3 (pIC50 = 10.2) antagonist-PDE4 (pIC50 = 8.8) inhibitor for the inhaled treatment of pulmonary diseases.

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> mAChR
Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)
Research Areas >> Others
Signaling Pathways >> GPCR/G Protein >> mAChR

[References]

[1]. Armani E, et al. Discovery of M3 Antagonist-PDE4 Inhibitor Dual Pharmacology Molecules for the Treatment of Chronic Obstructive Pulmonary Disease. J Med Chem. 2021 Jul 8;64(13):9100-9119.

Chemical & Physical Properties

[ Molecular Formula ]:
C36H37Cl2N3O7S

[ Molecular Weight ]:
726.67

Related Compounds