Acetyl-CoA Carboxylase-IN-1

Names

[ Name ]:
Acetyl-CoA Carboxylase-IN-1

[Synonym ]:
6-arylpyrido[2,3-d]pyrimidine deriv. 18
QC-198
6-(2,6-dibromo-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine
2v58

Biological Activity

[Description]:

Acetyl-CoA Carboxylase-IN-1 is a potent acetyl-CoA carboxylase (ACC) inhibitor with an IC50 value of ＜5 nM. Acetyl-CoA Carboxylase-IN-1 has antibacterial activity[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Metabolic Enzyme/Protease >> Acetyl-CoA Carboxylase

Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

Acetyl-CoA Carboxylase-IN-1 (compound 1; 0.012-25 μM; 大肠杆菌) 具有抗菌活性，对于 WT、WT+ PMBN、ΔacrAB、ΔacrAB+PMBN、ΔtolC 和 ΔtolC+ PMBN 的 MIC 值分别为 >25、3.13、25、0.39、1.56 和 0.1 μM[1]。

[References]

[1]. Cifone MT, et, al. Heterobivalent Inhibitors of Acetyl-CoA Carboxylase: Drug Target Residence Time and Time-Dependent Antibacterial Activity. J Med Chem. 2022 Dec 22;65(24):16510-16525.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₃H₉Br₂N₅

[ Molecular Weight ]:
395.05200

[ Exact Mass ]:
392.92200

[ PSA ]:
90.71000

[ LogP ]:
4.54360

Safety Information

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%