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2,5-Dihydroxycinnamic Acid phenethyl ester

Names

[ CAS No. ]:
179691-97-5

[ Name ]:
2,5-Dihydroxycinnamic Acid phenethyl ester

[Synonym ]:
2-Phenylethyl (2E)-3-(2,5-dihydroxyphenyl)acrylate
2-phenylethyl (2E)-3-(2,5-dihydroxyphenyl)prop-2-enoate
β-Phenylethyl 2,5-dihydroxycinnamate
2-Propenoic acid, 3-(2,5-dihydroxyphenyl)-, 2-phenylethyl ester, (2E)-

Biological Activity

[Description]:

5-LOX-IN-2, an inhibitor of 5-lipoxygenase (5-LOX) with an IC50 of 0.33 μM, inhibits 5-LOX in a dose-dependent manner . 5-LOX-IN-2, reduces the cell viability of renal cancer cells and induces apoptosis, can be used for cancer research[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase

[Target]

5-LOX:0.33 μM (IC50)


[References]

[1]. Selka A, et.al. Discovery of a novel 2,5-dihydroxycinnamic acid-based 5-lipoxygenase inhibitor that induces apoptosis and may impair autophagic flux in RCC4 renal cancer cells. Eur J Med Chem. 2019 Oct 1;179:347-357.  

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
515.5±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C17H16O4

[ Molecular Weight ]:
284.31

[ Flash Point ]:
192.2±23.6 °C

[ Exact Mass ]:
284.104858

[ LogP ]:
3.70

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.646

Related Compounds