E3 ligase Ligand-Linker Conjugates 12

E3 ligase Ligand-Linker Conjugates 12 is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology.

Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate

Research Areas >> Cancer

E3 Ligase Ligand-Linker Conjugate[1]

E3 ligase Ligand-Linker Conjugates 12 is extracted from patent WO/2016/146985A1, figure 11. PROTAC has been developed having structure A-L-B that can tether a bromodomain inhibitor via a moiety which binds to a protein within the bromo- and Extra-terminal (BET) family of proteins to a small molecule E3 ubiquintin ligase protein binding ligand compond via a suitable linker[1][2].

[1]. WO/2016/146985A1

[2]. Zengerle M, et al. Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4. ACS Chem Biol. 2015 Aug 21;10(8):1770-7.

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